Theme: Novel Approaches in Cell Science, Stem Cell Research and Regenerative Medicine
Cell Science 2018
Tracks:
1. Cell Science Research: Cell Science Research studies cells – their physiological properties, their structure, the organelles they contain, interactions with their environment, their life cycle, division, death and cell function.
· Advances in Cell Sciences and Tissue Engineering
· Molecular Biology of the Cell
· Cell Line Development for novel molecules
· The role of genetic and epigenetic factors in development
· Advances in cell and gene therapy
· Market wide and global applications
· Medical Diagnosis and repair
· Physical, Chemical & Systems Cell Biology
Related Conferences: 9th International Conference & Exhibition on Tissue Preservation and Biobanking, Nov 9-10 2018, Atlanta, USA; 2nd Annual Summit on Cell Signaling and Cancer Therapy, Sep 19-20, 2018, Philadelphia, USA; 10th World Congress and Expo on Cell & Stem Cell Research, March 19-21, 2018 in New York, USA; 2nd Annual Summit on Cell Therapy and Stem Cell Research, Nov 9-10, 2018, Atlanta, USA; 2nd World Biotechnology Congress, Dec 4-5 2017, Sao Paulo, Brazil; Cell & Gene Therapy World Event, Jan 22-25, 2018, Miami, USA; Combined CAR-T Congress Europe, Jan 30-31, 2018, Berlin, Germany; Annual Cell and Gene Therapy Innovation Summit, Feb 7-8, 2018, Berlin, Germany; 3rd Annual Genome Editing & Engineering Conference, Feb 8-9, 2018, San Diego, CA, USA; International Society for BioProcess Technology 8th Spring Meeting- Viral vectors and vaccines, Mar 5-7, 2018, Norfolk, Virginia.
2. Cell & Gene Therapy: Gene therapy is defined as a set of strategies that modify the expression of an individual’s genes or repair abnormal genes. Each strategy involves the administration of a specific nucleic acid (DNA or RNA). Nucleic acids are normally not taken up by cells, thus special carriers; so-called 'vectors' are required. Vectors can be of either viral or non-viral nature whereas Cell therapy is defined as the administration of living whole cells into the patient for the treatment of a disease. The origin of the cells can be from the same individual (autologous source) or from another individual (allogeneic source). Cells can be derived from stem cells, such as bone marrow or induced pluripotent stem cells (iPSCs), reprogrammed from skin fibroblasts or adipocytes. Stem cells are applied in the context of bone marrow transplantation directly. Other strategies involve the application of more or less mature cells, differentiated in vitro (in a dish) from stem cells.
Related Conferences: 2nd Annual Summit on Cell Signaling and Cancer Therapy, Sep 19-20, 2018, Philadelphia, USA; 2nd Annual Summit on Cell Therapy and Stem Cell Research, Nov 9-10, 2018, Atlanta, USA; 2nd World Biotechnology Congress, Dec 4-5 2017, Sao Paulo, Brazil; 9th International Conference & Exhibition on Tissue Preservation and Biobanking, Nov 9-10 2018, Atlanta, USA; 10th World Congress and Expo on Cell & Stem Cell Research, March 19-21, 2018 in New York, USA; British Society for Gene and Cell Therapy (BSGCT) Public Engagement, Mar 15, 2018, Oxford, UK; International Society for Cellular Therapy (ISCT) Annual Meeting, May 2-5, 2018, Montreal, Canada; American Society of Gene and Cell Therapy (ASGCT) 21ST Annual Meeting, May 16-19, 2018, Chicago, IL, USA; Gene Therapy Bioproduction Conference, Aug 13-16, 2018, Boston, USA; XXVI Congress of the European Society of Gene and Cell Therapy (ESGCT), Oct 16-19, 2018, Lausanne, Switzerland.
3. Stem Cells: An undifferentiated mass of cell in a multicellular organism which is capable of giving rise to indefinite number of cells of the same type, and from which certain other kinds of cell arise by differentiation. Stem cells have the ability to differentiate into specific cell types. The two defining characteristics of a stem cell are perpetual self-renewal and the ability to differentiate into a specialized adult cell type. There are two major classes of stem cells: pluripotent that can become any cell in the adult body, and multipotent that is restricted to becoming a more limited population of cells.
· Stem Cell Treatment
· Stem cell Nano-technology
· Stem Cell Technologies
· Somatic Cell Therapy
· Pluripotent Stem Cell Based Cancer Therapy
· Neural Stem Cells Therapy
· Stem Cell Therapy for Corneal Regeneration in The Eye
· Cardiac Stem Cell Therapeutics
Related Conferences: 2nd Annual Summit on Cell Therapy and Stem Cell Research, Nov 9-10, 2018, Atlanta, USA; 2nd World Biotechnology Congress, Dec 4-5 2017, Sao Paulo, Brazil; 9th International Conference & Exhibition on Tissue Preservation and Biobanking, Nov 9-10 2018, Atlanta, USA; 2nd Annual Summit on Cell Signaling and Cancer Therapy, Sep 19-20, 2018, Philadelphia, USA; 10th World Congress and Expo on Cell & Stem Cell Research, March 19-21, 2018 in New York, USA; British Society for Gene and Cell Therapy (BSGCT) Annual Conference Autumn 2018, Nov 23, 2018, London, UK; XXVII Congress of the European Society of Gene and Cell Therapy (ESGCT), Oct 28-31, 2018, Barcelona, Spain; International Society for Stem Cell Research (ISSCR) 2018 Annual Meeting, June 20-23, 2018, Melbourne, Australia; The 2018 World Stem Cell Summit, Jan 22-26, 2018, Miami, Florida; ICSCB 2018 : 20th International Conference on Stem Cell Biology, March 12-13, 2018, Miami, USA
4. Regenerative Medicine: Regenerative Medicine refers to a group of biomedical approaches to research and clinical applications which are aimed at replacing or "regenerating" human cells, tissues or organs to restore or establish normal functions which were disrupted due to diseases. The field of Regenerative medicine has attracted much attention as it holds the promise of regenerating damaged tissues and organs in the body by replacing damaged tissue or by stimulating the body's own repair mechanisms to heal damaged tissues or organs. It also may enable scientists to grow tissues and organs in the laboratory and safely implant them within the body. Regenerative solutions thus can be a revolutionary step in the field of healthcare.
· Regeneration Manufacturing Challenges for Regenerative Medicine
· Regenerative Medicine Market
· Nanotechnology In The Regeneration of Complex Tissues
· Organ Printing
Related Conferences: 9th International Conference & Exhibition on Tissue Preservation and Biobanking, Nov 9-10 2018, Atlanta, USA; 2nd Annual Summit on Cell Signaling and Cancer Therapy, Sep 19-20, 2018, Philadelphia, USA; 10th World Congress and Expo on Cell & Stem Cell Research, March 19-21, 2018 in New York, USA; 2nd Annual Summit on Cell Therapy and Stem Cell Research, Nov 9-10, 2018, Atlanta, USA; 2nd World Biotechnology Congress, Dec 4-5 2017, Sao Paulo, Brazil; Cell & Gene Therapy World Event, Jan 22-25, 2018, Miami, USA; Combined CAR-T Congress Europe, Jan 30-31, 2018, Berlin, Germany; Annual Cell and Gene Therapy Innovation Summit, Feb 7-8, 2018, Berlin, Germany; 3rd Annual Genome Editing & Engineering Conference, Feb 8-9, 2018, San Diego, CA, USA; International Society for BioProcess Technology 8th Spring Meeting- Viral vectors and vaccines, Mar 5-7, 2018, Norfolk, Virginia.
5. Tissue Engineering: Tissue engineering is widely used in the biomedical sector for regeneration and repair of diseased or trauma tissues. Tissue engineering addresses tissue and organ failure by implanting natural, synthetic, or semisynthetic tissue and organ mimics that are fully functional from the start or that grow into the required functionality. The field initially focused on skin equivalents for treating burns, but an increasing number of tissue types are now being engineered, as well as biomaterials and scaffolds are being used as delivery systems successfully. A variety of approaches are used to coax differentiated or undifferentiated cells, such as stem cells, into the desired cell type.
· Soft Tissue Engineering
· Musculoskeletal tissue regeneration
· Tissue mechanics and mechanobiology
Related Conferences: 2nd Annual Summit on Cell Therapy and Stem Cell Research, Nov 9-10, 2018, Atlanta, USA; 2nd World Biotechnology Congress, Dec 4-5 2017, Sao Paulo, Brazil; 9th International Conference & Exhibition on Tissue Preservation and Biobanking, Nov 9-10 2018, Atlanta, USA; 2nd Annual Summit on Cell Signaling and Cancer Therapy, Sep 19-20, 2018, Philadelphia, USA; 10th World Congress and Expo on Cell & Stem Cell Research, March 19-21, 2018 in New York, USA; British Society for Gene and Cell Therapy (BSGCT) Annual Conference Autumn 2018, Nov 23, 2018, London, UK; XXVII Congress of the European Society of Gene and Cell Therapy (ESGCT), Oct 28-31, 2018, Barcelona, Spain; International Society for Stem Cell Research (ISSCR) 2018 Annual Meeting, June 20-23, 2018, Melbourne, Australia; The 2018 World Stem Cell Summit, Jan 22-26, 2018, Miami, Florida; ICSCB 2018 : 20th International Conference on Stem Cell Biology, March 12-13, 2018, Miami, USA
6. Applications of Tissue Engineering: There are many applications of Tissue engineering but majorly they are used in Organ Transplantation and Therapeutic Cloning like Bio Artificial liver device, artificial pancreas, artificial bladders, and Cartilage. When there is damage in our body cells or organs we use tissue engineering techniques to overcome the damage by replacing the old cell. There is wide range of Tissue Engineered product or materials which are used to cure diseases in human and save life.
· Modular Tissue Engineering
· Tissue Remodeling
· Scaffold Design
· Tissue Printing
· Cell Sheet Technologies
· Additive Photo Cross-linking
· Modeling Human Physiology
Related Conferences: 2nd Annual Summit on Cell Signaling and Cancer Therapy, Sep 19-20, 2018, Philadelphia, USA; 2nd Annual Summit on Cell Therapy and Stem Cell Research, Nov 9-10, 2018, Atlanta, USA; 2nd World Biotechnology Congress, Dec 4-5 2017, Sao Paulo, Brazil; 9th International Conference & Exhibition on Tissue Preservation and Biobanking, Nov 9-10 2018, Atlanta, USA; 10th World Congress and Expo on Cell & Stem Cell Research, March 19-21, 2018 in New York, USA; British Society for Gene and Cell Therapy (BSGCT) Public Engagement, Mar 15, 2018, Oxford, UK; International Society for Cellular Therapy (ISCT) Annual Meeting, May 2-5, 2018, Montreal, Canada; American Society of Gene and Cell Therapy (ASGCT) 21ST Annual Meeting, May 16-19, 2018, Chicago, IL, USA; Gene Therapy Bioproduction Conference, Aug 13-16, 2018, Boston, USA; XXVI Congress of the European Society of Gene and Cell Therapy (ESGCT), Oct 16-19, 2018, Lausanne, Switzerland.
7. Bio Imaging & Bio printing Tissues and Organs: 3D bioprinting refers to the process of creating cell patterns in a confined space using 3D printing technologies, where cell function and viability are preserved within the printed construct.
· Organ printing
· 3D Printed Organ Transplants
· 3D Bio printing Tissues & Organs
· Computer-aided design
· Computer simulation Modeling
Related Conferences: 9th International Conference & Exhibition on Tissue Preservation and Biobanking, Nov 9-10 2018, Atlanta, USA; 2nd Annual Summit on Cell Signaling and Cancer Therapy, Sep 19-20, 2018, Philadelphia, USA; 10th World Congress and Expo on Cell & Stem Cell Research, March 19-21, 2018 in New York, USA; 2nd Annual Summit on Cell Therapy and Stem Cell Research, Nov 9-10, 2018, Atlanta, USA; 2nd World Biotechnology Congress, Dec 4-5 2017, Sao Paulo, Brazil; Cell & Gene Therapy World Event, Jan 22-25, 2018, Miami, USA; Combined CAR-T Congress Europe, Jan 30-31, 2018, Berlin, Germany; Annual Cell and Gene Therapy Innovation Summit, Feb 7-8, 2018, Berlin, Germany; 3rd Annual Genome Editing & Engineering Conference, Feb 8-9, 2018, San Diego, CA, USA; International Society for BioProcess Technology 8th Spring Meeting- Viral vectors and vaccines, Mar 5-7, 2018, Norfolk, Virginia.
8. Immunotherapy: Immunotherapy is treatment that uses your body's own immune system to help fight cancer.
· Cancer Immunotherapy
· Non- Surgical & Surgical therapies
· Immunosuppression Challenges
Related Conferences: 2nd Annual Summit on Cell Therapy and Stem Cell Research, Nov 9-10, 2018, Atlanta, USA; 2nd World Biotechnology Congress, Dec 4-5 2017, Sao Paulo, Brazil; 9th International Conference & Exhibition on Tissue Preservation and Biobanking, Nov 9-10 2018, Atlanta, USA; 2nd Annual Summit on Cell Signaling and Cancer Therapy, Sep 19-20, 2018, Philadelphia, USA; 10th World Congress and Expo on Cell & Stem Cell Research, March 19-21, 2018 in New York, USA; British Society for Gene and Cell Therapy (BSGCT) Annual Conference Autumn 2018, Nov 23, 2018, London, UK; XXVII Congress of the European Society of Gene and Cell Therapy (ESGCT), Oct 28-31, 2018, Barcelona, Spain; International Society for Stem Cell Research (ISSCR) 2018 Annual Meeting, June 20-23, 2018, Melbourne, Australia; The 2018 World Stem Cell Summit, Jan 22-26, 2018, Miami, Florida; ICSCB 2018 : 20th International Conference on Stem Cell Biology, March 12-13, 2018, Miami, USA
9. Translational Medicine: Translational medicine is a rapidly growing discipline in biomedical research and aims to expedite the invention of latest diagnostic tools and treatments by using a multi-disciplinary, very collaborative; "bench-to-bedside" approach. Within public health, translational medicine is concentrated on ensuring that established strategies for disease treatment and prevention are actually implemented within the community. Therefore, Translational Medicine is outlined as an interdisciplinary branch of the biomedical field supported by three main pillars that are bench side, bedside, and community.
· Clinical & Translational Medicine
· Biomarker Development
· Targeted Clinical Trials
Related Conferences: 9th International Conference & Exhibition on Tissue Preservation and Biobanking, Nov 9-10 2018, Atlanta, USA; 2nd Annual Summit on Cell Signaling and Cancer Therapy, Sep 19-20, 2018, Philadelphia, USA; 10th World Congress and Expo on Cell & Stem Cell Research, March 19-21, 2018 in New York, USA; 2nd Annual Summit on Cell Therapy and Stem Cell Research, Nov 9-10, 2018, Atlanta, USA; 2nd World Biotechnology Congress, Dec 4-5 2017, Sao Paulo, Brazil; Cell & Gene Therapy World Event, Jan 22-25, 2018, Miami, USA; Combined CAR-T Congress Europe, Jan 30-31, 2018, Berlin, Germany; Annual Cell and Gene Therapy Innovation Summit, Feb 7-8, 2018, Berlin, Germany; 3rd Annual Genome Editing & Engineering Conference, Feb 8-9, 2018, San Diego, CA, USA; International Society for BioProcess Technology 8th Spring Meeting- Viral vectors and vaccines, Mar 5-7, 2018, Norfolk, Virginia.
10. Biomaterials in Regenerative Medicine: Biomaterials are being employed for the health care applications from ancient times. However subsequent evolution has made them a lot versatile and has multiplied their utility. Biomaterials have revolutionized areas like bioengineering, tissue engineering and Regenerative Medicine for the development of novel methods to combat life-threatening diseases. Alongside biomaterials, stem cell technology is additionally getting used to enhance the present aid facilities.
· Hydrogels
· Biopolymers
· Cell sheets
· Nanofabricated scaffolds
Related Conferences: 2nd Annual Summit on Cell Signaling and Cancer Therapy, Sep 19-20, 2018, Philadelphia, USA; 2nd Annual Summit on Cell Therapy and Stem Cell Research, Nov 9-10, 2018, Atlanta, USA; 2nd World Biotechnology Congress, Dec 4-5 2017, Sao Paulo, Brazil; 9th International Conference & Exhibition on Tissue Preservation and Biobanking, Nov 9-10 2018, Atlanta, USA; 10th World Congress and Expo on Cell & Stem Cell Research, March 19-21, 2018 in New York, USA; British Society for Gene and Cell Therapy (BSGCT) Public Engagement, Mar 15, 2018, Oxford, UK; International Society for Cellular Therapy (ISCT) Annual Meeting, May 2-5, 2018, Montreal, Canada; American Society of Gene and Cell Therapy (ASGCT) 21ST Annual Meeting, May 16-19, 2018, Chicago, IL, USA; Gene Therapy Bioproduction Conference, Aug 13-16, 2018, Boston, USA; XXVI Congress of the European Society of Gene and Cell Therapy (ESGCT), Oct 16-19, 2018, Lausanne, Switzerland.
11. Ethical Issues and Challenges: The regulation of stem cell research is an issue that has drawn much comment, criticism and even judicial arbitration in recent years.
Related Conferences: 2nd Annual Summit on Cell Therapy and Stem Cell Research, Nov 9-10, 2018, Atlanta, USA; 2nd World Biotechnology Congress, Dec 4-5 2017, Sao Paulo, Brazil; 9th International Conference & Exhibition on Tissue Preservation and Biobanking, Nov 9-10 2018, Atlanta, USA; 2nd Annual Summit on Cell Signaling and Cancer Therapy, Sep 19-20, 2018, Philadelphia, USA; 10th World Congress and Expo on Cell & Stem Cell Research, March 19-21, 2018 in New York, USA; British Society for Gene and Cell Therapy (BSGCT) Annual Conference Autumn 2018, Nov 23, 2018, London, UK; XXVII Congress of the European Society of Gene and Cell Therapy (ESGCT), Oct 28-31, 2018, Barcelona, Spain; International Society for Stem Cell Research (ISSCR) 2018 Annual Meeting, June 20-23, 2018, Melbourne, Australia; The 2018 World Stem Cell Summit, Jan 22-26, 2018, Miami, Florida; ICSCB 2018 : 20th International Conference on Stem Cell Biology, March 12-13, 2018, Miami, USA
12. Commercialization: Carefully planned and ethically approved clinical trials resulting from a robust preclinical pathway are necessary to advance the field. This will require a programmatic approach that involves partnerships of clinicians, academics, industry, and regulatory authorities with a focus on understanding basic biology that informs a tight linkage between preclinical and clinical studies. Rather than suggesting that clinical trials are premature, such trials should be encouraged as part of multidisciplinary programs in regenerative medicine.
Related Conferences: 9th International Conference & Exhibition on Tissue Preservation and Biobanking, Nov 9-10 2018, Atlanta, USA; 2nd Annual Summit on Cell Signaling and Cancer Therapy, Sep 19-20, 2018, Philadelphia, USA; 10th World Congress and Expo on Cell & Stem Cell Research, March 19-21, 2018 in New York, USA; 2nd Annual Summit on Cell Therapy and Stem Cell Research, Nov 9-10, 2018, Atlanta, USA; 2nd World Biotechnology Congress, Dec 4-5 2017, Sao Paulo, Brazil; Cell & Gene Therapy World Event, Jan 22-25, 2018, Miami, USA; Combined CAR-T Congress Europe, Jan 30-31, 2018, Berlin, Germany; Annual Cell and Gene Therapy Innovation Summit, Feb 7-8, 2018, Berlin, Germany; 3rd Annual Genome Editing & Engineering Conference, Feb 8-9, 2018, San Diego, CA, USA; International Society for BioProcess Technology 8th Spring Meeting- Viral vectors and vaccines, Mar 5-7, 2018, Norfolk, Virginia.
Conference Series LLC Ltd invites all the participants from all over the world to attend '11th World Congress on Cell Science, Stem Cell Research & Regenerative Medicine’ during March December 07-08, 2018 Chicago, USA which includes prompt keynote presentations, oral talks, poster presentations and exhibitions.
Cell Science 2018 will also provide the excellent opportunity to meet experts, exchange information, and strengthen the collaboration among Directors, Researchers, Associate Professors, and Scholars from both academia and industry.
11th World Congress on Cell Science Stem Cell Research & Regenerative Medicine is anticipating participants from 40 and more countries across the globe and the two day conference will provoke plenary sessions, keynote speeches, posters, and oral presentations. This program provides two days of robust discussions on recent advancements and new strategies for development of new materials for global requirements.
Cell Science and Stem Cell Research 2018 have the platform to fulfil the prevailing gaps in the transformation of this science of hope, to serve promptly with solutions to all in the need. Cell Science and Stem Cell Research 2018 will have an anticipated participation of 120+ delegates across the world to discuss the innovations and novel technics in the current field.
Success Story: Cell Science Conference Series LLC Ltd
The success of the Cell Science Conference Series LLC Ltd has given us the prospect to bring the gathering in Chicago, USA. Since its commencement in 2011 Cell Science series has witnessed around 2500+ researchers of great potentials and outstanding research presentations from around the world. Awareness of stem cells and its application is becoming popular among the general population. Parallel offers of hope add woes to the researchers of cell science due to the potential limitations experienced in the real-time.
About Organizers
Conference Series LLC Ltd is one of the leading Open Access publishers and organizers of international scientific conferences and events every year across USA, Europe & Asia ConferenceSeries LLC Ltd has so far organized 3000+ global conferences with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business with 700+ peer-reviewed open access journals in basic science, health, and technology. Conference Series LLC Ltd is also in association with more than 1000 International scientific and technological societies and associations and a team of 30,000 eminent scholars, reputed scientists as editorial board members.
Scientific Sessions
Cell Science and Stem Cell Research 2018 brings you an immense opportunity to be a part of scientific acceleration to world class personalities, young scholars, scientific delegates and young scientists to join in this forum to utilize the expertise and novelties that brings a new era for innovations in the field of Cell Science, Stem Cell Research and Regenerative Medicine which brings well versed scrutinizers at one place. It provides a platform to have open discussions, knowledge sharing and interactive sessions with field experts at Cell Science 2018.
Cell Science and Stem Cell Research 2018 will encompass recent researches and findings in stem cell technologies, stem cell therapies and transplantations, current understanding of cell plasticity in cancer and other advancements in stem cell research and cell science. Cell Science and Stem Cell Research 2018 will be a great platform for research scientists and young researchers to share their current findings in this field of applied science. The major scientific sessions in Stem Cell Research 2018 will focus on the latest and exciting innovations in prominent areas of cell science and stem cell research.
Target Audience:
Eminent personalities, Directors, CEO, President, Vice-president, Organizations, Associations heads and Professors, Research scientists, Stem Cell laboratory heads, Post-docs, Students other affiliates related to the area of stem cell research, stem cell line companies can be as Target Audience.
Currently Cell Science has emerged as a widely diverse field with the potential to address the worldwide organ shortage issue and comprises of tissue regeneration and organ replacement. The global market for tissue engineering and regeneration is expected to reach $60.8 billion by 2021 from $13.6 billion in 2016, rising at a compound annual growth rate (CAGR) of 34.9% from 2016 through 2021.
The global market for stem cells reached over $5.9 billion in the year 2015 and will grow from about $6.7 billion in 2016 to nearly $12.3 billion in 2021, registering a compound annual growth rate (CAGR) of 13.1% from 2016 through 2021.
The global market for induced pluripotent stem cells (iPSCs) was estimated to total $853 million in 2012 and close to $1.2 billion in 2013, averaging 40% growth. The market is expected to reach $2.9 billion in 2018, an estimated compound annual growth rate (CAGR) of 19.7% for the five-year period 2013 to 2018.
Competition is currently intense among companies trying to create brand awareness. This is therefore, compelling the market players to formulate market based strategies. Cord blood stem cell is the only type of stem cell that is stored in controlled condition due to its lower volume higher cell count feature. Storage service market is expected grow at 33.4% CAGR from 2013-2020.
The U.S. market for regenerative medicine products used only in bone and joint applications is expected to grow at a compound annual growth rate (CAGR) of 6.8% from $2.9 billion in 2015 to nearly $4.1 billion in 2020.
Global regenerative medicines market is projected to reach $30,237 million by 2022. Cell therapy segment is expected to dominate the market throughout the forecast period. North America led the global market in 2015, and is expected to remain dominant during the 2015-2022.
Top players in the market:
Conference Highlights
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Conference Date | December 07-08, 2018 | ||
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Useful Links
Special Issues
All accepted abstracts will be published in respective Our International Journals.
- Journal of Cell Science & Therapy
- Journal of Stem Cell Research & Therapy
- Cell & Developmental Biology
Abstracts will be provided with Digital Object Identifier by